Immunity to Cryptosporidium muris infection in mice is expressed through gut CD4+ intraepithelial lymphocytes
نویسندگان
چکیده
منابع مشابه
Gut intraepithelial lymphocytes induce immunity against Cryptosporidium infection through a mechanism involving gamma interferon production.
Immunological control of infection with cryptosporidia in mice is dependent on CD4+ T cells and the production of gamma interferon (IFN-gamma), but to date, the mucosal T cells which produce IFN-gamma local to the infection have not been characterized. We previously showed that immunity against the gastric parasite Cryptosporidium muris could be adoptively transferred to adult SCID (severe comb...
متن کاملIrradiated β-glucan enhances immune response to bacterial infection through CD4 and CD8 T-lymphocytes
Background: &beta-glucans are glucose polymers with a variety of stimulatory effects on the immune system. The objective of this study was to evaluate the immune-enhancing activities of low molecular weight gamma irradiated &beta-glucan (I&beta-g) extracted from Pleurotus ostreatus in response to Pseudomonas aeruginosa infection in rats. Materials and Methods: &beta-glucan (&beta-g) powder was ...
متن کاملAge-dependent resistance to Cryptosporidium muris (strain MCR) infection in golden hamsters and mice.
An age-dependent aspect of resistance to Cryptosporidium muris (strain MCR) infection was monitored in Syrian golden hamsters, Mesocricetus auratus, at 1-, 5- and 10-week of age and in ICR mice. Mus musculus, at 3-, 12-, and 15-week of age orally inoculated with a single dose of 2 x 10(6) oocysts, respectively. The prepatent periods for both animals were similar, independent of age, but the pat...
متن کاملTHE ROLE OF B-CELLS IN THE DEVELOPMENT OF IMMUNITY TO CRYPTOSPORIDIUM INFECTION
Studies have shown that symptomatic improvement of cryptosporidiosis in immunocompromised patients is possible following treatment with" hyperimmune" colostrum containing anti-sporozoite antibodies from cattle immunized with Cryptosporidium parvum antigens. The contribution to immunity of antibodies developed during Cryptosporidium infection is unclear, however. Previously, we showed that ...
متن کاملComparison of Resistance to γ-Irradiation between Cryptosporidium parvum and Cryptosporidium muris Using In Vivo Infection
In the genus Cryptosporidium, there are more than 14 species with different sizes and habitats, as well as different hosts. Among these, C. parvum and C. hominis are known to be human pathogens. As C. parvum can survive exposure to harsh environmental conditions, including various disinfectants or high doses of radiation, it is considered to be an important environmental pathogen that may be a ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1996
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.64.7.2556-2562.1996